MODEL ADEQUACY IN ASSESSING THE PREDICTIVE PERFORMANCE OF REGRESSION MODELS IN PHARMACEUTICAL PRODUCT OPTIMIZATION: THE BEDAQUILINE SOLID LIPID NANOPARTICLE EXAMPLE

This study aimed to assess the predictive performance of first- and second-order regression models in optimizing bedaquiline (BQ) solid lipid nanoparticle (SLN) formulations.A three-step central composite design and graphical optimization process was employed.A design of experiments method was used to evaluate the impact of BQ, Tween 80 (T80), poly

The incidence of food allergies in western countries has bilstein shocks jeep xj increased dramatically in recent decades.Tolerance to food antigens relies on mucosal CD103+ dendritic cells (DCs), which promote differentiation of regulatory T (Treg) cells.We show that high-fiber feeding in mice improved oral tolerance and protected from food allerg

Worldwide, a huge amount of solid fermented waste is produced every year during mushroom production.The rational utilization of spent mushroom substrate (SMS) is conducive to environmental protection and the sustainable development of agriculture.The aims of this work were to analyze the effects of the SMS mulching thickness on the soil environment